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High-sensitivity C-reactive protein levels and cancer mortality
Young-Jin Ko1, Young-Min Kwon, Kyae Hyung Kim
1Department of Family Medicine, Center for Health Promotion, Seoul National University Hospital, Seoul, South Korea.
Summary
Elevated high-sensitivity C-reactive protein (hs-CRP) indicates increased cancer mortality risk, particularly lung cancer in men. This inflammatory marker helps identify individuals at higher risk for cancer death.
Area of Science:
- Biomarkers
- Inflammation
- Oncology
Background:
- Inflammation plays a role in cancer initiation and progression.
- High-sensitivity C-reactive protein (hs-CRP) is a key inflammatory marker.
Purpose of the Study:
- To investigate the association between serum hs-CRP levels and mortality in apparently cancer-free Koreans.
- To examine all-cause, cancer-specific, and site-specific cancer mortality risks based on hs-CRP levels.
Main Methods:
- Study included 33,567 participants with available serum hs-CRP data.
- Follow-up for mortality occurred from baseline until December 31, 2008 (average 9.4 years).
Main Results:
- Elevated hs-CRP (≥3 mg/L) was linked to increased all-cause and cancer mortality in men.
- A trend of increased mortality was observed in women, though not statistically significant.
- Elevated hs-CRP was associated with a significantly higher risk of lung cancer mortality in both sexes combined.
Conclusions:
- Elevated hs-CRP levels in apparently cancer-free individuals may predict increased all-cause and cancer mortality.
- hs-CRP can serve as a valuable marker for identifying individuals at elevated risk of cancer death, especially lung cancer in men.
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