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Updated: May 17, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Association of proinsulin and hepatic steatosis in a random, population-based sample
Sonja Wengert1, Suemeyra Oeztuerk, Mark Martin Haenle
1Department of Internal Medicine I, University Hospital Ulm, Albert-Einstein-Allee 23, D-89081 Ulm, Germany.
Objective:
Proinsulin may represent a predictive marker for assessing insulin resistance and reduced β-cell function. The objective of this study was to investigate the association between hepatic steatosis, proinsulin and other parameters in a random, population-based sample.
Design:
Cross-sectional study, conducted in south-western Germany.
Methods:
Upper abdominal ultrasound examinations were performed in 343 subjects (147 females, 196 males; average age 40.0±11.5 years). Proinsulin, the proinsulin-to-insulin ratio and other laboratory parameters were determined, and the BMI, waist-to-hip ratio (WHR) and other anthropometric data were documented.
Results:
HEPATIC STEATOSIS WAS OBSERVED IN 80 SUBJECTS (23.3%: 29.6%, males; 15.0%, females). Multivariate analysis showed an association with hepatic steatosis for male gender (P=0.0212), advancing age (P=0.0241), elevated BMI (P<0.0001), elevated WHR (P=0.0024), alanine aminotransferase (P=0.0046), proinsulin (P=0.0403) and proinsulin-to-insulin ratio (P=0.0116).
Conclusions:
There is an association between elevated proinsulin concentrations and hepatic steatosis.
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