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Related Experiment Video

Updated: May 17, 2026

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Real-time Imaging of Myeloid Cells Dynamics in Apc^Min/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

DPC4 expression in the small intestinal adenocarcinomas.

Sun Jae Lee¹, Eunsil Yu, Young Kyung Bae

¹Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.

Korean Journal of Pathology

|November 9, 2012

Summary

This summary is machine-generated.

Smad4/DPC4 loss was observed in 12.8% of small intestinal adenocarcinomas (SACs). This loss correlated with increased lymphatic invasion risk but not survival, suggesting a role in SAC progression.

Keywords:

Adenocarcinoma Immunohistochemistry Intestine, small Smad4/DPC4

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Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Published on: January 3, 2013

Area of Science:

Oncology
Gastroenterology
Molecular Pathology

Background:

Small intestinal adenocarcinomas (SACs) are rare gastrointestinal malignancies.
The carcinogenesis of SACs remains poorly understood.

Purpose of the Study:

To investigate the expression of Smad4/DPC4 in a large cohort of SACs.
To correlate Smad4/DPC4 expression with clinicopathological features and patient survival.

Main Methods:

Utilized tissue microarray technology for immunohistochemical analysis.
Examined 188 surgically resected SAC cases for Smad4/DPC4 expression.
Correlated expression levels with tumor location, differentiation, invasion, and metastasis.

Main Results:

Complete loss of Smad4/DPC4 expression occurred in 12.8% of SACs.
Smad4/DPC4 expression was linked to an increased risk of lymphatic invasion.
No significant association was found between Smad4/DPC4 expression and patient survival or other clinicopathological features.

Conclusions:

This is the first large-scale study correlating Smad4/DPC4 expression with clinicopathology in SACs.
Further research into the immunohistochemical and molecular aspects of SACs is needed to elucidate their tumorigenesis.