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Ghost cell odontogenic carcinoma arising from calcifying cystic odontogenic tumor: a case report
Zhi-Yu Zhu1, Zhi-Gang Chu, Yu Chen
1Department of Pathology, West China Hospital of Stomatology, Sichuan University, Sichuan, China.
Abstract:
Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.