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[Transgenerational effects of prenatal stress of different etiology]

A V Graf, T Iu Dunaeva, A S Maklakova

    Izvestiia Akademii Nauk. Seriia Biologicheskaia
    |November 10, 2012
    PubMed

    Insights

    Prenatal stress impacts offspring across generations, affecting physical development, stress response, and behavior. These effects can persist for at least four generations, highlighting the long-term consequences of early-life adversity.

    Area of Science:

    • Reproductive biology
    • Developmental biology
    • Neuroendocrinology

    Context:

    • Prenatal stress exposure can originate from diverse sources.
    • Understanding its long-term consequences is crucial for developmental and health outcomes.
    • Effects are studied across multiple generations (F1-F4).

    Purpose:

    • To investigate the transgenerational effects of prenatal stress on various biological and functional parameters.
    • To assess the impact of stress etiology on maternal, fetal, and offspring health.
    • To explore the mechanisms underlying the transmission of stress effects across generations.

    Summary:

    • Evaluates biochemical and morphofunctional changes in mothers, fetuses, and offspring (F1-F4) following prenatal stress.
    • Focuses on physical development, hypothalamic-pituitary-adrenal axis function, inflammation, behavior, cognition, and autonomic balance.
    • Considers current theories on the mechanisms of transgenerational stress effect transmission.

    Impact:

    • Provides insights into the lasting health implications of prenatal stress.
    • Informs potential interventions for mitigating adverse transgenerational effects.
    • Contributes to understanding the biological basis of inherited stress responses.

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