Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 17, 2026

Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics
09:12

Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics

Published on: May 28, 2016

Chemically isolating hot spots on concave nanocubes.

Matthew Rycenga1, Mark R Langille, Michelle L Personick

  • 1Department of Chemistry and International Institute of Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.

Nano Letters
|November 10, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Structural Enthalpy in Spherical Nucleic Acid Hybridization.

Journal of the American Chemical Society·2018
Same author

The Weak-Link Approach to the Synthesis of Inorganic Macrocycles.

Angewandte Chemie (International ed. in English)·2018
Same author

Ligand Design for Electrochemically Controlling Stoichiometric and Catalytic Reactivity of Transition Metals.

Angewandte Chemie (International ed. in English)·2018
Same author

The Electrical Properties of Gold Nanoparticle Assemblies Linked by DNA.

Angewandte Chemie (International ed. in English)·2018
Same author

Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks.

Angewandte Chemie (International ed. in English)·2018
Same author

PLGA Spherical Nucleic Acids.

Advanced materials (Deerfield Beach, Fla.)·2018
Same journal

Spider-Silk-Like Single-Fiber Actuators with Two Actuation Modes Driven by Water.

Nano letters·2026
Same journal

Clicking 1,4-Dithiin Conjugated Dimaleimides for Chiroptical Evolution and Nanofabrication.

Nano letters·2026
Same journal

Dynamic Quantum Gate Based on Controllable Chiral Liquid Crystal Nanostructure.

Nano letters·2026
Same journal

Activating Phase-Transition Toughening in van der Waals Semiconductor GaTe.

Nano letters·2026
Same journal

Dual-Mode Nucleation and Dynamic Alloying of Silicon on Ag(111).

Nano letters·2026
Same journal

Surface-Neutralized HgCdSe Quantum Dots for High-Detectivity Infrared Photodetectors.

Nano letters·2026
See all related articles

Researchers developed a method to modify the sharp corners of concave nanocubes, enhancing their SERS hot spots. This technique selectively exposes and functionalizes these regions for improved signal response.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Surface Chemistry

Background:

  • Concave nanocubes possess unique geometric features.
  • Sharp corners of nanocubes act as Surface-Enhanced Raman Spectroscopy (SERS) hot spots.
  • Controlled functionalization of these hot spots is crucial for enhancing SERS performance.

Purpose of the Study:

  • To develop a general strategy for selective exposure and functionalization of concave nanocube corners.
  • To leverage the unique shape of concave nanocubes for targeted SERS hot spot modification.
  • To improve SERS enhancement and signal response by functionalizing specific regions.

Main Methods:

  • Coating concave nanocubes with silica.
  • Selective etching of the silica coating to expose corner regions.

More Related Videos

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Fabrication and Operation of a Nano-Optical Conveyor Belt
11:10

Fabrication and Operation of a Nano-Optical Conveyor Belt

Published on: August 26, 2015

Related Experiment Videos

Last Updated: May 17, 2026

Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics
09:12

Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics

Published on: May 28, 2016

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Fabrication and Operation of a Nano-Optical Conveyor Belt
11:10

Fabrication and Operation of a Nano-Optical Conveyor Belt

Published on: August 26, 2015

  • Functionalization of the exposed corner regions.
  • Utilizing the unique shape of concave cubes to maintain silica coating on faces.

    • Main Results:

    • Successfully exposed and functionalized the sharp corners of concave nanocubes.
    • Demonstrated selective modification of SERS hot spots.
    • Achieved improved SERS enhancement and signal response.

    Conclusions:

    • The developed strategy offers a simple and general approach for tailoring SERS hot spots.
    • Selective functionalization of concave nanocube corners significantly boosts SERS performance.
    • This method provides a pathway for designing advanced SERS substrates.