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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

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Published on: February 4, 2011

Gravity driven deterministic lateral displacement for particle separation in microfluidic devices.

Raghavendra Devendra¹, German Drazer

¹Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Analytical Chemistry

|November 10, 2012

Summary

This summary is machine-generated.

Gravity-driven deterministic lateral displacement (g-DLD) devices enable continuous particle separation. Specific forcing angles achieve vector separation, guiding g-DLD device design for efficient size-fractionation.

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Area of Science:

Fluid dynamics
Particle separation technology
Microfluidics

Background:

Deterministic Lateral Displacement (DLD) is a microfluidic technique for particle separation.
Gravity-driven DLD (g-DLD) offers a passive method for particle manipulation.
Understanding particle behavior under gravity and obstacle interactions is crucial for device optimization.

Purpose of the Study:

To investigate two-dimensional continuous size-based separation of suspended particles using g-DLD.
To identify optimal forcing orientations for achieving vector separation in g-DLD devices.
To provide design guidance for developing efficient g-DLD separation systems.

Main Methods:

Experimental investigation of particle trajectories in g-DLD devices across various forcing orientations.
Development and application of a predictive model based on particle-obstacle interactions.
Analysis of directional locking phenomena and its dependence on particle size.

Main Results:

Identification of specific forcing angles that induce vector separation, where particles migrate in distinct average directions.
A simple model accurately predicts migration angle based on forcing direction and particle-obstacle interactions.
Observation of particle-size-dependent directional locking, indicating suitability of small forcing angles for size-fractionation.

Conclusions:

g-DLD devices can achieve continuous, size-based particle separation.
Optimal forcing angles and understanding particle-obstacle interactions are key for effective g-DLD design.
Demonstrated high-resolution separation of binary particle mixtures using specific small forcing angles.