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Safety of urate-lowering therapies: managing the risks to gain the benefits
1Duke Gout and Crystal Arthropathies Clinic, Duke Specialty Infusion Center, Durham, NC 27710, USA. robert.keenan@duke.edu
Abstract:
Gout is a metabolic disorder of purine metabolism and uric acid elimination. Over time, acute gout can develop into a chronic, disabling arthropathy, often associated with multiple comorbidities. Gout patients have often been undertreated, partly because of the clinician's perceived risks of a therapy outweighing its potential benefits. The approval of new therapies to treat hyperuricemia in gout has led to a new understanding of gout management and medication safety regarding new and old therapies. This review focuses on potential safety issues of currently available urate-lowering therapies and outlines strategies to minimize risks so their benefits can be reached.
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