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Related Experiment Video

Updated: May 17, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Cutaneous microvascular dysfunction correlates with serum LDL and sLOX-1 receptor concentrations.

W Larry Kenney1, Joseph G Cannon, Lacy M Alexander

  • 1Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA.

Microvascular Research
|November 10, 2012
PubMed
Summary

High LDL cholesterol, a risk factor for atherosclerosis, impairs skin blood vessel function. This study shows reduced nitric oxide-dependent vasodilation in the skin correlates with elevated LDL and oxidized LDL levels.

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

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Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

  • Cardiovascular Physiology
  • Atherosclerosis Pathogenesis
  • Microvascular Function

Background:

  • Human cutaneous circulation serves as a model for microvascular dysfunction, an early aspect of atherosclerosis.
  • Elevated low-density lipoproteins (LDL) are atherogenic and linked to coronary atherosclerosis severity via lectin-like oxidized LDL receptors (LOX-1).

Purpose of the Study:

  • To investigate the correlation between cutaneous microvascular dysfunction and serum markers of LDL cholesterol.
  • To assess if endothelial nitric oxide- (NO-) dependent vasodilation is impaired in relation to LDL, oxidized LDL, and soluble LOX-1 (sLOX-1) levels.

Main Methods:

  • 53 healthy adults (aged 52±8 years) with varying LDL levels (72-233 mg/dL) participated.
  • Skin blood flow was measured using laser Doppler flowmetry during local heating (42°C).
  • Nitric oxide-dependent vasodilation was quantified by blocking NO synthase with L-NAME and normalizing to maximal cutaneous vascular conductance (CVC).

Main Results:

  • NO-dependent vasodilation significantly decreased as a linear function of serum LDL concentration (R(2)=0.303, p<0.001).
  • Impaired vasodilation was also correlated with higher levels of oxidized LDL (R(2)=0.214, p<0.001) and soluble LOX-1 (R(2)=0.259, p=0.026).
  • No significant relationship was found between vasodilation and high-density lipoprotein (HDL) concentration (R(2)=0.003, p=0.68).

Conclusions:

  • Hypercholesterolemia-induced microvascular dysfunction is associated with elevated LDL and oxidized LDL markers.
  • This dysfunction involves a progressive reduction in NO-dependent vasodilation, which is measurable in the skin microcirculation.