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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

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Related Experiment Videos

A case of pyodermatitis-pyostomatitis vegetans.

Hongmei Wang1, Shufang Qiao, Xiujun Zhang

  • 1Department of Dermatology, Tianjin Changzhen Hospital, Tianjin, China. yyy961030@163.com

The American Journal of the Medical Sciences
|November 10, 2012
PubMed
Summary
This summary is machine-generated.

Pyodermatitis-pyostomatitis vegetans (PD-PSV), a rare mucocutaneous disorder linked to inflammatory bowel disease, can be effectively treated. A case study shows remission of PD-PSV lesions with human albumin and methylprednisolone therapy.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Gastroenterology
  • Immunology

Background:

  • Pyodermatitis-pyostomatitis vegetans (PD-PSV) is a rare mucocutaneous disorder.
  • It is frequently associated with underlying inflammatory bowel disease (IBD).

Observation:

  • A 42-year-old woman with ulcerative colitis presented with an 11-month history of verrucous and pyogenic lesions.
  • Lesions affected the scalp, neck, axillae, inguinal areas, umbilicus, trunk, and oral cavity, accompanied by fatigue and lower extremity swelling.

Findings:

  • Histopathology showed eosinophilic inflammation, microabscesses, and pseudoepitheliomatous hyperplasia.
  • Direct immunofluorescence was negative for IgA, IgG, and C3.
  • The patient was diagnosed with PD-PSV.

Implications:

  • Treatment with human albumin infusions followed by methylprednisolone resulted in lesion remission within one month.
  • This case highlights a successful therapeutic approach for PD-PSV.
  • Understanding the differential diagnosis between PD-PSV and pemphigus vegetans is crucial.