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Oral aphthosis: management gaps and recent advances
Michelle W Liang1, Ching Yin Neoh
1National Skin Centre, Singapore 308205. mliang@nsc.gov.sg
Annals of the Academy of Medicine, Singapore
|November 10, 2012
Summary
Oral aphthosis significantly impacts quality of life. This study highlights the need for improved management strategies and monitoring for Behcet's disease progression, especially in complex cases.
Area of Science:
- Dermatology
- Oral Medicine
Background:
- Oral aphthosis is a common condition affecting patient quality of life.
- It is the most frequent oral ulcerative condition in clinical practice.
- This study examines oral aphthosis patterns in Singapore to identify management gaps and underlying conditions.
Purpose of the Study:
- To characterize oral aphthosis patterns at a tertiary dermatological center.
- To evaluate management gaps in oral aphthosis treatment.
- To identify associated systemic diseases and nutritional deficiencies in patients with oral aphthosis.
Main Methods:
- Retrospective review of 213 patient records from June 2000 to June 2010.
- Inclusion criteria focused on oral ulcers, aphthous ulcers, oral aphthosis, and Behcet's disease.
- Exclusion of Behcet's disease without oral ulcers and other oral ulcerative conditions like pemphigus vulgaris, lichen planus, and herpes simplex.
Main Results:
- 175 patients were included; 101 had recurrent oral aphthosis (77 simple, 24 complex).
- 14 patients (8%) met International Study Criteria for Behcet's disease, predominantly with complex aphthosis (85.71%).
- Treatments ranged from topical steroids and colchicine to oral corticosteroids and dapsone.
Conclusions:
- Dermatologists are well-positioned to manage recurrent oral aphthosis.
- A defined management and therapeutic algorithm is needed for improved patient outcomes.
- Complex aphthosis requires monitoring for potential progression to Behcet's disease.
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