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Updated: May 17, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
[Update: Behçet's disease]
1Zentrum für Interdisziplinäre Rheumatologie Stuttgart (ZIRS), Rheumatologische Schwerpunktpraxis, Seelbergstr. 11, 70372, Stuttgart, Deutschland. ina.koetter@uni-tuebingen.de
Abstract:
Behçet's disease (BD) is now mentioned in the latest Chapel Hill nomenclature of vasculitides and is classified under the variable vessel vasculitides (VVV). Pathogenetically, a new classification among the so-called mixed-pattern diseases between classical polygenic autoinflammatory disorders and autoimmune diseases is being discussed. The genetic association with HLA-B51 is undisputed and an association with HLA-A26 as well as with polymorphisms in the IL-10 and IL23R-IL12RB2 genes have recently been described. Increasingly, a participation of IL-17 in the pathogenesis of BD is assumed. Therapeutically, the EULAR recommendations are still applicable. Interferon-alpha can be discontinued for severe ocular BD in remission without further relapses. Infliximab can be switched to adalimumab effectively and recent case series show an efficacy of IL-1 antagonists, tocilizumab and rituximab for BD.
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