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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Updated: May 17, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

[Update: Behçet's disease].

I Kötter1

  • 1Zentrum für Interdisziplinäre Rheumatologie Stuttgart (ZIRS), Rheumatologische Schwerpunktpraxis, Seelbergstr. 11, 70372, Stuttgart, Deutschland. ina.koetter@uni-tuebingen.de

Zeitschrift Fur Rheumatologie
|November 10, 2012
PubMed
Summary
This summary is machine-generated.

Behçet's disease (BD) is classified as a variable vessel vasculitis. Research explores its genetic links to HLA-B51 and immune genes, with IL-17 potentially playing a role in its pathogenesis.

Related Experiment Videos

Last Updated: May 17, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Context:

  • Behçet's disease (BD) is reclassified under variable vessel vasculitides (VVV) in the latest Chapel Hill nomenclature.
  • Pathogenesis is debated, potentially bridging autoinflammatory and autoimmune disease categories.
  • Genetic associations include HLA-B51, HLA-A26, and polymorphisms in IL-10 and IL23R-IL12RB2 genes.

Purpose:

  • To review the current understanding of Behçet's disease classification, pathogenesis, and therapeutic strategies.
  • To highlight emerging genetic associations and the potential role of IL-17.
  • To discuss updated therapeutic recommendations and novel treatment options.

Summary:

  • Behçet's disease (BD) is now classified as a variable vessel vasculitis (VVV).
  • Genetic factors like HLA-B51 and immune gene polymorphisms are implicated, with increasing evidence for IL-17 involvement in pathogenesis.
  • Current therapies align with EULAR recommendations, with specific adjustments for interferon-alpha and effective switching strategies between biologics like infliximab and adalimumab.

Impact:

  • Provides an updated overview of Behçet's disease for clinicians and researchers.
  • Informs understanding of the complex genetic and immunological underpinnings of BD.
  • Guides therapeutic decisions based on the latest evidence and recommendations.