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Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...

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Related Experiment Video

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Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
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Lady Prelox® improves sexual function in post-menopausal women.

A Bottari1, G Belcaro, A Ledda

  • 1Irvine3 Circulation-Vascular Labs, Department of Biomedical Sciences, Chieti-Pescara University, Pescara, Italy - cardres@abol.it.

Panminerva Medica
|November 10, 2012
PubMed
Summary

This pilot study found that Lady Prelox®, a dietary supplement, significantly improved sexual function in post-menopausal women. The supplement demonstrated greater efficacy than placebo in enhancing desire, arousal, lubrication, orgasm, satisfaction, and reducing pain.

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Area of Science:

  • Reproductive Medicine
  • Nutritional Science
  • Women's Health

Background:

  • Menopause is associated with changes in sexual function.
  • Dietary supplements are being explored for managing menopausal symptoms.
  • Female sexual dysfunction (FSD) impacts quality of life.

Purpose of the Study:

  • To evaluate the efficacy of Lady Prelox® in improving sexual function in post-menopausal women.
  • To assess the impact of Lady Prelox® on the domains of the Female Sexual Function Index (FSFI).

Main Methods:

  • Pilot, single-blinded study with two groups: Lady Prelox® (n=40) and placebo (n=43).
  • Participants were generally healthy, post-menopausal women aged approximately 50 years.
  • The Female Sexual Function Index (FSFI) was used to measure sexual function over an eight-week period.

Main Results:

  • Lady Prelox® significantly increased total FSFI scores from baseline (44.6) to 70.9 at 4 weeks and 71.7 at 8 weeks.
  • The placebo group showed non-significant increases in total FSFI scores (44.1 at baseline to 47.4 at 8 weeks).
  • Lady Prelox® demonstrated significantly greater efficacy than placebo (P<0.05) across all six FSFI domains.

Conclusions:

  • Lady Prelox® shows promise as a new treatment option for women with moderate sexual function impairment.
  • Further research with larger cohorts, including premenopausal and perimenopausal women, is warranted.
  • The supplement was well-tolerated with no reported adverse effects.