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Updated: May 17, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
The relationship between grey-matter and ASD and ADHD traits in typical adults
Hilde M Geurts1, K Richard Ridderinkhof, H Steven Scholte
1Brain and Cognition, Department of Psychology, Universiteit van Amsterdam, Weesperplein 4, 1018 XA, Amsterdam, The Netherlands. h.m.geurts@uva.nl
Abstract:
We tested whether in 85 healthy adults (18-29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities.
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