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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.

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Related Experiment Video

Updated: May 17, 2026

Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

Systems genetics in "-omics" era: current and future development.

Hong Li1

  • 1Key Laboratory of Catalysis Science and Technology of Chongqing Education Commission, College of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing Nanan Xuefu Avenue 22#, Chongqing, 400067, People's Republic of China. lhctbu@163.com

Theory in Biosciences = Theorie in Den Biowissenschaften
|November 10, 2012
PubMed
Summary
This summary is machine-generated.

Systems genetics integrates high-throughput expression profiling and systems biology to uncover complex trait mechanisms. This approach enhances understanding of gene function, biochemical pathways, and genetic interactions for future genetic discoveries.

Related Experiment Videos

Last Updated: May 17, 2026

Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

Area of Science:

  • Genetics
  • Systems Biology
  • Bioinformatics

Background:

  • Systems genetics is an emerging field integrating high-throughput expression profiling and systems biology.
  • Bioinformatics is crucial for analyzing gene functions, genetic interactions (SNP-SNP, miRNA-mRNA, DNA-protein, protein-protein), and linkage disequilibrium (LD) block mapping.
  • Systems biology provides a foundational understanding of biological phenomena, paving the way for systems genetics.

Purpose of the Study:

  • To reveal the molecular mechanisms underlying complex traits.
  • To improve the understanding of gene functions within biochemical pathways.
  • To elucidate genetic interactions between biological molecules.

Main Methods:

  • High-throughput expression profiling
  • Systems biology approaches
  • Bioinformatics analysis of '-omics' datasets
  • Next-generation sequencing
  • Post-genome-wide association studies

Main Results:

  • Enhanced understanding of gene functions and biological processes.
  • Identification of molecular mechanisms driving complex traits.
  • Integration of diverse datasets (e.g., '-omics', sequencing) for knowledge extraction.

Conclusions:

  • Systems genetics offers a powerful framework for dissecting complex traits.
  • Integration of advanced technologies and strategies will refine theoretical frameworks.
  • This field promises significant contributions to the future of genetics and discovery of new genes/variants.