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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Flavour identification in frontotemporal lobar degeneration.

Rohani Omar¹, Colin J Mahoney, Aisling H Buckley

¹Dementia Research Centre, UCL Institute of Neurology, London WC1N 3BG, UK.

Journal of Neurology, Neurosurgery, and Psychiatry

|November 10, 2012

Summary

Frontotemporal lobar degeneration (FTLD) impairs flavour identification, particularly in behavioural variant FTD and semantic variant PPA. This deficit is linked to grey matter loss in specific brain regions.

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Area of Science:

Neuroscience
Neurology
Clinical Psychology

Background:

Flavour processing deficits are clinically significant in frontotemporal lobar degeneration (FTLD).
Understanding these deficits is crucial for managing FTD-related symptoms.

Purpose of the Study:

To investigate flavour identification abilities in patients with FTLD.
To correlate these deficits with brain structure and specific FTD subtypes.

Main Methods:

Prospective study of 25 FTD patients (bvFTD, svPPA, nfvPPA) and 17 controls.
Utilized a novel cross-modal flavour identification test.
Assessed odour identification and performed voxel-based morphometry on brain MRI scans.

Main Results:

FTLD patients, especially bvFTD and svPPA subgroups, showed significant flavour identification deficits.
All FTLD subgroups exhibited impaired odour identification.
Flavour identification correlated with grey matter volume in the left entorhinal cortex, hippocampus, parahippocampal gyrus, and temporal pole.

Conclusions:

FTLD syndromes are associated with impaired flavour identification.
This impairment is linked to grey matter atrophy in the anteromedial temporal lobe.
Findings may inform understanding of abnormal eating behaviors in FTLD.