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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Published on: December 15, 2011

Parthenium dermatitis.

Vinod Kumar Sharma1, Parul Verma, K Maharaja

  • 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, Teaching Block, 4th floor, Ansari Nagar, New Delhi, India. aiimsvks@yahoo.com

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|November 10, 2012
PubMed
Summary
This summary is machine-generated.

Parthenium dermatitis, common in India, is caused by Parthenium hysterophorus allergens. Research explores the shift from airborne contact dermatitis to chronic actinic dermatitis, investigating potential photosensitivity mechanisms.

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Area of Science:

  • Dermatology
  • Allergology
  • Environmental Health

Background:

  • Parthenium hysterophorus causes allergic contact dermatitis (ACD), prevalent in India.
  • The primary allergens are sesquiterpene lactones (SQLs), found in plant parts and trichomes.
  • Parthenium dermatitis presents in various forms, including airborne contact dermatitis and chronic actinic dermatitis (CAD).

Purpose of the Study:

  • To investigate the changing patterns of Parthenium dermatitis, specifically the transition from airborne to CAD.
  • To explore the potential mechanisms behind photosensitivity in Parthenium dermatitis.
  • To understand the role of environmental factors, like sunlight, in Parthenium dermatitis prevalence.

Main Methods:

  • Literature review and analysis of clinical presentation patterns.
  • Examination of allergen properties, particularly sesquiterpene lactones (SQLs) and their photoreactivity.
  • Consideration of environmental factors influencing Parthenium plant growth and allergenicity.

Main Results:

  • A trend shows Parthenium dermatitis evolving from airborne to CAD patterns.
  • Chronic actinic dermatitis (CAD) involves increased sensitivity to UVB, UVA, and visible light.
  • While SQLs are the main allergens, their photoallergic or phototoxic properties are not fully established.
  • The photoreactivity of the α-methylene-γ-butyrolactone ring is a proposed mechanism for photosensitivity.
  • Sunlight and UV radiation may enhance Parthenium allergenicity and plant growth, particularly in warmer seasons.

Conclusions:

  • Parthenium dermatitis is shifting towards a chronic actinic dermatitis pattern.
  • The exact mechanism of photosensitivity in Parthenium dermatitis requires further investigation.
  • Environmental factors, including sunlight, likely influence the prevalence and presentation of Parthenium dermatitis.