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Related Experiment Video

Updated: May 17, 2026

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Published on: June 5, 2012

Th2 responses in schistosomiasis.

Keke Fairfax¹, Marcia Nascimento, Stanley Ching-Cheng Huang

¹Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Seminars in Immunopathology

|November 10, 2012

Summary

This summary is machine-generated.

Schistosomiasis, a parasitic flatworm infection, involves complex immune responses. Understanding the regulation of Th2 responses is crucial for developing resistance and managing tissue damage.

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Last Updated: May 17, 2026

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

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Published on: June 5, 2012

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

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Published on: August 16, 2011

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Published on: January 14, 2018

Area of Science:

Immunology
Parasitology
Infectious Diseases

Background:

Schistosomiasis is caused by parasitic flatworms of the genus Schistosoma.
Infection triggers strong CD4(+) T cell and B cell responses.
These responses fail to eliminate parasites but enable host survival amid tissue damage.

Purpose of the Study:

To investigate the induction and regulation of T helper 2 (Th2) responses in schistosomiasis.
To understand the dual role of Th2 responses in fibrosis and resistance to infection.

Main Methods:

This study focuses on the immunological mechanisms underlying schistosomiasis.
Analysis of host-parasite interactions and immune cell involvement.

Main Results:

A tightly controlled Th2 response is essential for host survival during primary infection.
While a risk factor for fibrosis, the Th2 response also confers resistance to reinfection.

Conclusions:

Understanding Th2 response regulation is critical for schistosomiasis control.
Further research into immune modulation could lead to novel therapeutic strategies.