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Published on: June 23, 2019
Design, synthesis and structure-activity relationship of novel insecticidal dichloro-allyloxy-phenol derivatives
Miao Li1, Chang-Ling Liu, Jing Zhang
1State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co. Ltd, Shenyang, China.
Background:
Pyridalyl, consisting of dicholoro-allyoxy-phenol moiety, is a novel class of insecticide showing extraordinary activities against various lepidopterous and thysanopterous pests on cotton and vegetables. To discover further novel insecticides, a series of new dichloro-allyloxy-phenol derivatives containing substituted pyrazol-3-ol moieties were designed and synthesised via the intermediate derivatisation method.
Results:
The target compounds were characterised by (1) H NMR, IR, MS and elemental analysis. Bioassays indicated that some of these compounds exhibited good insecticidal activities against diamondback moth (Plutella xylostella) at 6.25 mg L(-1) . The structure-activity relationship is discussed.
Conclusion:
The present work demonstrates that dichloro-allyloxy-phenol derivatives with substituted phenylpyrazole moieties can be used as lead compounds to develop further novel insecticides.
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