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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Adiponectin and long-term mortality in coronary artery disease participants and controls

Sébastien Hascoet1, Meyer Elbaz, Vanina Bongard

  • 1Department of Cardiology, Rangueil Hospital, 1 avenue Jean Poulhes, 31000 Toulouse, France. shascoet.cardiotoulouse@yahoo.fr

Arteriosclerosis, Thrombosis, and Vascular Biology
|November 10, 2012
PubMed

Insights

High serum adiponectin predicts mortality, especially from cardiovascular disease, in both coronary artery disease (CAD) patients and controls. This prognostic value is independent of CAD severity and metabolic status.

Area of Science:

  • Cardiology
  • Biomarkers
  • Epidemiology

Background:

  • Adiponectin possesses cardioprotective properties, but its role as a cardiovascular disease marker remains debated due to conflicting study results.
  • Previous research on adiponectin and cardiovascular outcomes has yielded inconsistent findings, necessitating further investigation.

Purpose of the Study:

  • To determine if serum adiponectin levels are associated with long-term mortality in individuals with stable coronary artery disease (CAD) and control subjects.
  • To evaluate the prognostic value of adiponectin considering varying degrees of CAD severity.

Main Methods:

  • A case-control design was employed with a median prospective follow-up of 8.1 years.
  • Serum adiponectin levels were measured in 715 CAD patients and 782 controls.
  • Statistical analyses included survival rate comparisons across adiponectin quartiles and multivariate adjustments.

Main Results:

  • Survival rates decreased significantly with increasing quartiles of serum adiponectin in CAD patients (P<0.001).
  • Higher adiponectin levels (≥9.1 µg/mL) were associated with lower survival rates in controls (P=0.035).
  • Elevated adiponectin concentrations predicted increased risk of total and cardiovascular disease mortality in both CAD patients and controls, even after adjustments.

Conclusions:

  • High serum adiponectin is a significant predictor of mortality, particularly cardiovascular disease mortality.
  • The prognostic significance of adiponectin persists regardless of coronary artery disease severity or metabolic status.
  • The association between high adiponectin and mortality risk does not differ between individuals with and without CAD.
Abstract

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