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Alzheimer's disease with vascular component: a distinct clinical entity?
Javier Olazarán1, Eloísa Navarro, José Manuel Rojo
1Hermanos Sangro Specialties Clinic, Service of Neurology, Gregorio Marañón University Hospital, Spain ; Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofía Foundation, Spain.
Background:
Longitudinal reports on the clinical features of patients with Alzheimer's disease (AD) and concomitant cerebrovascular disease are scarce.
Methods:
We elaborated a working definition of AD with vascular component (ADVC), and this definition was retrospectively investigated in a cohort of patients with cognitive deterioration who were prescribed a cholinesterase inhibitor during usual practice.
Results:
A total of 137 patients with probable AD and 66 patients with ADVC were studied during a mean follow-up period of 2.8 years. Univariate analyses demonstrated worse functional evolution and anticipation of psychotic symptoms and agitation in the ADVC group.
Conclusions:
The present results are consistent with an additive model of predominantly frontal-subcortical vascular damage in AD.
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