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Related Experiment Video

Updated: May 17, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Remote ischemic preconditioning (RIPC) modifies plasma proteome in humans.

Michele Hepponstall1, Vera Ignjatovic, Steve Binos

  • 1Haematology Research, Murdoch Childrens Research Institute; Melbourne, Victoria, Australia.

Plos One
|November 10, 2012
PubMed
Summary

Remote Ischemic Preconditioning (RIPC) alters plasma proteins. This study reveals RIPC cumulatively modifies the peripheral blood proteome, impacting acute phase response and cellular functions.

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Area of Science:

  • Physiology
  • Proteomics
  • Cardiovascular Research

Background:

  • Remote Ischemic Preconditioning (RIPC) protects organs from ischemia-reperfusion (IR) injury.
  • RIPC's effects on gene expression are known, but its impact on the plasma proteome remains unclear.

Purpose of the Study:

  • To investigate RIPC-induced changes in the human plasma proteome.
  • To identify specific proteins regulated by RIPC in peripheral blood.

Main Methods:

  • Five healthy volunteers underwent forearm RIPC (4 cycles of 5 min ischemia/5 min reperfusion).
  • Plasma samples collected at multiple time points were analyzed using 2D DIGE and LC-MS.
  • Proteomic analysis identified differentially regulated proteins.

Main Results:

  • 2D DIGE identified 6 proteins altered by RIPC.
  • LC-MS analysis revealed 48 differentially regulated proteins.
  • Affected proteins were associated with acute phase response and cellular functions.

Conclusions:

  • RIPC cumulatively modifies the plasma protein profile in the ischemic arm.
  • RIPC elicits a measurable proteomic response in peripheral blood.
  • These findings provide insights into RIPC's systemic effects.