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Updated: May 17, 2026
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Microinjectrode System for Combined Drug Infusion and Electrophysiology
Published on: November 13, 2019
Micro and nanosystems for delivering local anesthetics.
Eneida de Paula1, Cíntia M S Cereda, Leonardo F Fraceto
1State University of Campinas, Institute of Biology, Department of Biochemistry, Campinas, SP, Brazil. depaula@unicamp.br
Expert Opinion on Drug Delivery
|November 13, 2012
Summary
Novel drug delivery systems enhance local anesthetics for prolonged pain control. This review details carrier systems like liposomes and biopolymers, crucial for effective pain management in medicine and dentistry.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Anesthesiology
Background:
- Local anesthetics are vital for surgical pain management.
- Drug delivery systems offer a safe method for prolonged analgesia.
- Choosing appropriate systems is key for each local anesthetic agent.
Purpose of the Study:
- To review drug delivery formulations for local anesthetics.
- To focus on prolonging anesthetic effects and reducing toxicity.
- To cover carrier systems for infiltrative administration.
Main Methods:
- Chronological literature review of drug delivery systems.
- Analysis of liposomes, biopolymers, and cyclodextrins.
- Examination of formulation advantages, pitfalls, and pharmacokinetics.
Main Results:
- Overview of carrier systems for local anesthetic administration.
- Discussion of pharmacokinetic data for various formulations.
- Summary of clinical studies in medicine and dentistry.
Conclusions:
- Future designs should optimize anesthetic upload and sustained release.
- Drug delivery systems are critical for advancing local anesthetic applications.
- This review provides the current state-of-the-art for clinical use.
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