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High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies
Published on: September 29, 2023
Renal transporters in drug development
Kari M Morrissey1, Sophie L Stocker, Matthias B Wittwer
1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA. kari.morrissey@ucsf.edu
Annual Review of Pharmacology and Toxicology
|November 13, 2012
Summary
The kidney eliminates toxic substances and drugs via proximal tubule transporters, crucial for drug interactions and clearance. Understanding these renal transporters impacts drug safety and efficacy.
Area of Science:
- Pharmacology
- Nephrology
- Drug Metabolism
Background:
- The kidney is essential for eliminating xenobiotics and metabolic waste.
- Proximal tubule secretory transporters significantly influence xenobiotic and drug disposition.
- Recent advancements highlight the role of renal transporters in drug-drug interactions.
Purpose of the Study:
- To review renal drug handling, clearance calculations, and the impact of transporters.
- To provide data on renal drug transporter localization, expression, substrates, and inhibitors.
- To discuss regulatory guidance, special populations, and transporter variants in renal drug elimination.
Main Methods:
- Literature review of renal drug handling and transporter function.
- Tabulation of data on renal drug transporters (localization, expression, substrates, inhibitors).
- Discussion of regulatory guidelines and special population considerations.
Main Results:
- Detailed description of renal drug handling and clearance equations (filtration and secretory).
- Comprehensive tables summarizing key characteristics of renal drug transporters.
- Analysis of the implications of renal transporters in drug-drug interactions and special populations.
Conclusions:
- Renal transporters are critical determinants of drug disposition and are sites of drug-drug interactions.
- Understanding renal transporter function is vital for optimizing drug therapy and predicting interactions.
- This review provides a comprehensive overview for researchers and clinicians studying renal drug transport.
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