Related Experiment Video

Updated: May 17, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Androgen receptor in human health: a potential therapeutic target

Hifzur Rahman Siddique1, Sanjeev Nanda, Aijaz Parray

  • 1Molecular Chemoprevention and Therapeutics, The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.

Current Drug Targets
|November 13, 2012
PubMed

Insights

Natural compounds show promise in inhibiting androgen receptor (AR) signaling, offering potential therapeutic strategies for AR-dependent diseases and aggressive malignancies. Research highlights their effectiveness across various administration routes.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Androgen Receptor (AR) activation is crucial in many diseases.
  • Androgen-independent AR activation occurs in aggressive human cancers.
  • Targeting AR is a key strategy for treating AR-dependent diseases.

Purpose of the Study:

  • To review natural compounds with potential pharmacological activity against AR signaling.
  • To summarize preclinical and clinical investigations of AR inhibitors.
  • To assess the utility of natural agents in combating AR-dependent conditions.

Main Methods:

  • Literature review of in vitro and preclinical animal studies.
  • Analysis of studies investigating natural compounds targeting AR.
  • Examination of AR signaling pathway inhibitors.

Main Results:

  • Several natural compounds demonstrate pharmacological efficacy against AR.
  • Natural agents show potential irrespective of administration route (oral, intravenous, etc.).
  • Compounds directly targeting AR are in preclinical and clinical development.

Conclusions:

  • Natural compounds represent a promising avenue for AR-targeted therapies.
  • Further research into natural agents could lead to novel treatments for AR-driven cancers.
  • Pharmacological inhibition of AR signaling is a viable therapeutic approach.

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

Related Concept Videos

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...