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Published on: August 22, 2017
A new method for a quantitative determination of piroxicam in pharmaceutical formulations using FT-IR spectrometry
Andrei A Bunaciu1, Şerban Fleschin, Hassan Y Aboul-Enein
1SCIENT - Research Center for Instrumental Analysis, (S.C. CROMATEC_PLUS S.R.L.), 18 Sos. Cotroceni, Bucharest - 6, 060114, Romania.
Abstract:
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can be determined by various methods and now we are adding a new one that uses a Fourier transform infrared spectrophotometric technique. Conventional spectra were compared for best determination of active substance in pharmaceutical formulations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.
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