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Celsr1-3 cadherins in PCP and brain development.
Camille Boutin1, André M Goffinet, Fadel Tissir
1Institute of Neuroscience, Developmental Neurobiology, Université Catholique de Louvain, Brussels, Belgium.
Current Topics in Developmental Biology
|November 13, 2012
Summary
Cadherin EGF LAG seven-pass G-type receptors (Celsr1-3) are crucial for planar cell polarity and brain development. This review explores their conserved and distinct roles in mammals and future research directions.
Area of Science:
- Cell Biology
- Developmental Biology
- Neuroscience
Background:
- Cadherin EGF LAG seven-pass G-type receptors (Celsr1-3) are atypical cadherins involved in epithelial and neural functions.
- Recent research highlights distinct roles for Celsr1-3 in planar cell polarity (PCP) and brain development and maintenance.
Purpose of the Study:
- To review the literature on Celsr1-3 in PCP and neural development.
- To identify remaining questions and future research trends in Celsr biology.
Main Methods:
- Literature review of studies on Celsr1-3.
- Analysis of conserved and distinct functions across species.
Main Results:
- Celsr proteins play conserved roles in PCP from flies to mammals.
- Celsr proteins exhibit distinct functions, potentially interacting with a subset of classical PCP partners.
Conclusions:
- Celsr1-3 are essential for both PCP and neural development.
- Further research is needed to elucidate the specific mechanisms and interactions of Celsr proteins in different biological contexts.
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