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Updated: May 17, 2026
07:07
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
Published on: February 21, 2016
The kidney and planar cell polarity.
1Department of Internal Medicine (Nephrology) and Molecular Biology, UT Southwestern Medical Center, Dallas, Texas, USA. Thomas.Carroll@UTSouthwestern.edu
Current Topics in Developmental Biology
|November 13, 2012
Summary
Planar cell polarity (PCP) regulates tissue development and maintenance. This review explores PCP
Area of Science:
- Developmental Biology
- Cell Biology
- Renal Physiology
Background:
- Planar cell polarity (PCP) describes coordinated cell orientation within a tissue plane, distinct from apical-basal polarity.
- PCP is crucial for tissue morphogenesis, evident in structures like Drosophila wings and mammalian hair cells.
- PCP's role in mammalian kidney development and maintenance remains less explored.
Purpose of the Study:
- To review the potential roles of planar cell polarity (PCP) in mouse kidney development and maintenance.
- To discuss underlying molecular and cellular mechanisms, including oriented cell division and cell migration.
- To identify and stimulate discussion on unaddressed research areas concerning PCP in the kidney.
Main Methods:
- Literature review of existing studies on planar cell polarity (PCP).
- Analysis of PCP's involvement in specific mouse kidney developmental processes.
- Discussion of potential regulatory mechanisms and future research directions.
Main Results:
- PCP is implicated in key mouse kidney developmental processes: ureteric bud branching, renal medulla elongation, tubule diameter regulation, and glomerulogenesis.
- Oriented cell division and coordinated cell migration/intercalation are proposed mechanisms for PCP in kidney development.
- PCP also plays a role in the kidney's response to injury.
Conclusions:
- Planar cell polarity (PCP) is a critical regulator of mouse kidney development, maintenance, and injury response.
- Further research into PCP mechanisms in the kidney is warranted to understand tissue morphogenesis and disease.
- Identifying specific PCP pathways in renal cells can reveal new therapeutic targets.
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