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Updated: May 17, 2026
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Synthesis and biological evaluation of ⁹⁹mTc(CO)₃(His-CB) as a tumor imaging agent
Jianjun Wang1, Jing Yang, Xiaojiang Duan
1Research Center for Applications of Nuclear Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People's Republic of China. wangjianjun@ihep.ac.cn
Abstract:
The chlorambucil l-histidine conjugate was synthesized and radiolabeled with [(99m)Tc(CO)(3)](+) core to form the (99m)Tc(CO)(3)(His-CB) complex. The radiochemical purity of the complex was over 90%. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with certain retention, fast clearance from background, good tumor/non-tumor ratios and satisfactory scintigraphic images highlighted the potential of (99m)Tc(CO)(3)(His-CB) as a tumor imaging agent.
