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Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
Published on: June 2, 2023
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Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture
Tasuku Hirayama1, Masayasu Taki, Kazushi Akaoka
1Graduate School of Human and Environmental Studies, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Bioorganic & Medicinal Chemistry Letters
|November 13, 2012
Abstract:
A synthetic peptide bearing a lanthanide complex, TbOTZ exhibits a decrease of chromophore fluorescence and a concomitant luminescence enhancement due to sensitized Tb(3+) upon Zn(2+) binding. Thus, TbOTZ can be a valuable tool for ratiometric sensing of Zn(2+) as well as for time-resolved fluorescence detection with a single molecule.

