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[Comparison on clinical features between dilated cardiomyopathy patients with or without pulmonary hypertension]

Wei-hua Zhang1, Hui Xu, Yang Zheng

  • 1Cardiovascular Diseases Center, First Hospital of Jilin University, Changchun , China.

Zhonghua Xin Xue Guan Bing Za Zhi
|November 13, 2012
PubMed

Insights

Pulmonary hypertension (PH) in dilated cardiomyopathy (DCM) patients is associated with more severe clinical features. DCM patients with PH showed worse heart function and higher bilirubin levels compared to those without PH.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Medical Diagnostics

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Pulmonary hypertension (PH) can be a complication of DCM, affecting prognosis.
  • Echocardiography is crucial for diagnosing DCM and assessing cardiac function.

Purpose of the Study:

  • To compare clinical data of DCM patients with and without pulmonary hypertension (PH).
  • To identify echocardiographic and clinical differences between DCM with PH and DCM without PH.

Main Methods:

  • Retrospective analysis of 112 DCM patients (61 with PH, 51 without PH) from January 2007 to December 2009.
  • Comparison of demographic, clinical, echocardiographic, and serum biomarker data.
  • Echocardiography was used for PH diagnosis and cardiac function assessment.

Main Results:

  • Patients with DCM and PH exhibited higher rates of NYHA class III/IV, larger left atrial and left ventricle dimensions, and increased right ventricular outflow tract dimensions.
  • DCM with PH group showed a higher incidence of pericardial effusion and elevated serum total bilirubin levels.
  • Ejective fraction was significantly lower in DCM patients with PH compared to those without PH, indicating poorer heart function.

Conclusions:

  • Pulmonary hypertension is associated with more severe clinical manifestations in dilated cardiomyopathy.
  • DCM patients with PH present with worse cardiac function and elevated bilirubin levels.
  • These findings highlight the clinical impact of PH on DCM progression and severity.
Abstract

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