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Updated: May 17, 2026
12:27
Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
Published on: January 3, 2020
Does sex affect 30-day mortality in Staphylococcus aureus bacteremia?
Nariman Mansur1, Rawi Hazzan, Mical Paul
1Pharmacy Services, Rabin Medical Center, Beilinson Hospital, and Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel. narimanm@clalit.org.il
Gender Medicine
|November 13, 2012
Summary
Women with Staphylococcus aureus bacteremia face higher mortality risks than men. This study found increased 30-day mortality in women, unexplained by other risk factors.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Epidemiology
Background:
- Sex-related differences in infection outcomes are debated.
- Further research is needed for Staphylococcus aureus infections.
Purpose of the Study:
- To examine S. aureus infection outcomes in men versus women.
- To determine if sex differences are explained by comorbidities, disease severity, or treatment.
Main Methods:
- A single-center cohort study (1988-2007).
- Included patients with S. aureus bacteremia.
- Compared 30-day all-cause mortality using multivariable logistic regression.
Main Results:
- 1093 patients with S. aureus bacteremia identified.
- 30-day mortality was 44.8% in women vs. 35.4% in men (P < 0.01).
- Female sex independently associated with higher mortality (OR=1.63).
Conclusions:
- Women with S. aureus bacteremia have a higher risk of 30-day mortality.
- This excess mortality in women remains unexplained by known risk factors.
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