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Silymarin for diabetic nephropathy: the challenges of botanical product research

Catherine M Meyers, Josephine P Briggs

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |November 13, 2012
    PubMed
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    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...