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Poststroke fatigue is associated with caudate infarcts.

W K Tang¹, H J Liang, Y K Chen

¹Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China. tangwk@cuhk.edu.hk

Journal of the Neurological Sciences

|November 13, 2012

Summary

Poststroke fatigue (PSF) is linked to caudate infarcts. This study found acute caudate infarcts are an independent predictor of PSF, suggesting a role for the caudate nucleus in stroke-related fatigue.

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Area of Science:

Neurology
Neuroscience
Stroke Research

Background:

The caudate nucleus's role in neurological fatigue is suggested.
The association between caudate lesions and poststroke fatigue (PSF) remains unclear.

Purpose of the Study:

To investigate the relationship between caudate infarcts and the occurrence of PSF.
To determine if caudate lesions are an independent predictor of PSF.

Main Methods:

A cohort of 500 Chinese acute ischemic stroke patients were assessed for PSF using the Fatigue Severity Scale (FSS) three months post-stroke.
Physical functioning (Barthel Index) and depressive symptoms (Geriatric Depression Scale) were also measured.
PSF was defined as an FSS score of 4.0 or higher.

Main Results:

25% of patients experienced PSF.
PSF patients had higher rates of caudate infarcts (8.0% vs. 1.3%, p=0.001) and putamen infarcts (19.2% vs. 12.0%, p=0.043) compared to non-fatigue patients.
Acute caudate infarcts were an independent predictor of PSF (OR=6.4).

Conclusions:

The findings suggest a significant association between caudate infarcts and poststroke fatigue.
The caudate nucleus may play a crucial role in the pathogenesis of PSF.