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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 17, 2026

An Automated Culture System for Maintaining and Differentiating Human-Induced Pluripotent Stem Cells
06:11

An Automated Culture System for Maintaining and Differentiating Human-Induced Pluripotent Stem Cells

Published on: January 26, 2024

Ethnically diverse pluripotent stem cells for drug development.

Eyitayo S Fakunle1, Jeanne F Loring

  • 1Department of Chemical Physiology, Center for Regenerative Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

Trends in Molecular Medicine
|November 13, 2012
PubMed
Summary
This summary is machine-generated.

Genetic variation impacts drug response. Induced pluripotent stem cells (iPSCs) offer a solution for incorporating diverse genetic backgrounds into drug development, potentially reducing adverse drug reactions and improving safety.

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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Last Updated: May 17, 2026

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An Automated Culture System for Maintaining and Differentiating Human-Induced Pluripotent Stem Cells

Published on: January 26, 2024

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
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Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Area of Science:

  • Pharmacogenomics
  • Drug Development
  • Stem Cell Biology

Background:

  • Genetic variation significantly influences drug efficacy and toxicity, leading to adverse drug reactions (ADRs).
  • ADRs, particularly liver toxicity, are a major cause of post-marketing drug failure.
  • Early detection of genetic predisposition to toxicity is crucial for drug development.

Purpose of the Study:

  • To explore the utility of induced pluripotent stem cells (iPSCs) in addressing the challenge of incorporating genetic diversity into drug development.
  • To discuss the benefits and challenges associated with using iPSCs for creating ethnically diverse cell line collections.

Main Methods:

  • Utilizing induced pluripotent stem cells (iPSCs) derived from diverse individuals.
  • Differentiating iPSCs into various relevant cell types for drug testing.
  • Leveraging iPSC self-renewal capacity for generating large, quality-controlled cell populations.

Main Results:

  • iPSCs can be generated from any individual, reflecting diverse genetic backgrounds.
  • iPSCs are amenable to differentiation into multiple cell types relevant for drug screening.
  • The self-renewal property of iPSCs enables scalable production of diverse cell models.

Conclusions:

  • iPSCs present a promising platform for introducing genetic diversity into preclinical drug development.
  • Using iPSC-derived cells can help predict drug efficacy and toxicity across diverse populations.
  • Addressing the challenges of iPSC generation and differentiation is key to realizing their full potential in personalized medicine.