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Updated: May 17, 2026
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Prognostic factors of extremity soft tissue sarcoma in adults. A single institutional analysis
I Atean1, Y Pointreau, P Rosset
1Department of Radiation Oncology, Henry-Kaplan Oncology Center, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours, France. alotain2002@gmail.com
Purpose:
To analyse the prognostic factors for patients treated with limb sparing surgery and radiation for extremity soft tissue sarcoma (E-STS).
Patients And Methods:
Medical records of 87 patients with limb sparing surgery and radiation for E-STS were reviewed retrospectively. Disease-free survival (DFS) and disease-specific survival (DSS) were estimated and factors potentially influencing these outcomes were analysed.
Results:
With a mean follow-up of 69months, most recurrences occurred within the first 2years. Extent of resection margin was found to improve DFS (P=0.002) and DSS (P=0.002). Brachytherapy combined with external beam radiotherapy (EBRT) improved DFS (P=0.034) and DSS (P=0.019). Tumor size (<10cm) was related to DSS (P=0.043) and its relation to DFS was almost significant (P=0.057). Short time interval between surgery and radiotherapy (≤50days) had an impact only on DSS (P=0.030).
Conclusion:
Extent of resection margin and use of brachytherapy combined with EBRT seem to improve the prognosis of E-STS. Small tumor size and short time interval between radiotherapy and surgery seem also to improve the outcome of E-STS. This study was limited by inadequate power and low number of recurrences. Larger randomised studies are needed to confirm these results.
