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Related Experiment Video

Updated: May 17, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Curcumin ameliorates arterial dysfunction and oxidative stress with aging.

Bradley S Fleenor¹, Amy L Sindler, Natasha K Marvi

¹Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. bradley.fleenor@uky.edu

Experimental Gerontology

|November 13, 2012

Summary

Curcumin supplementation reversed age-related arterial stiffening and vascular oxidative stress in mice. This natural compound improved endothelial function and reduced collagen and advanced glycation end-products, suggesting potential for treating arterial aging.

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Last Updated: May 17, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Published on: June 16, 2014

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Area of Science:

Cardiovascular Research
Aging Biology
Nutritional Science

Background:

Aging is associated with arterial stiffening and vascular oxidative stress.
These age-related changes contribute to endothelial dysfunction and increased risk of cardiovascular disease.

Purpose of the Study:

To investigate the effects of curcumin supplementation on age-associated arterial dysfunction and vascular oxidative stress in mice.
To determine if curcumin can reverse established arterial aging markers.

Main Methods:

Young and old male C57BL6/N mice were fed either a standard or curcumin-supplemented diet for 4 weeks.
Arterial stiffness was assessed using aortic pulse wave velocity (aPWV).
Vascular endothelial function, nitric oxide bioavailability, and markers of oxidative stress were evaluated ex vivo.

Main Results:

Old mice exhibited increased arterial stiffness, collagen I, and advanced glycation end-products (AGEs), with reduced elastin compared to young mice.
Curcumin supplementation in old mice normalized aPWV, collagen I, and AGEs to levels seen in young mice.
Curcumin restored endothelial-dependent dilation and nitric oxide (NO) bioavailability in old mice, and reversed oxidative stress markers including nitrotyrosine and superoxide production.

Conclusions:

Curcumin supplementation effectively ameliorates age-associated arterial stiffening and vascular endothelial dysfunction in mice.
The findings suggest curcumin reduces oxidative stress and improves vascular health by modulating collagen and AGEs.
Curcumin shows promise as a potential therapeutic agent for combating arterial aging in humans.