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Published on: March 30, 2017
Developing and advancing dry powder inhalation towards enhanced therapeutics
S Stegemann1, S Kopp, G Borchard
1Capsugel, Bornem, Belgium. sven.stegemann@capsugel.com
Summary
Enhanced therapeutics offer innovation in drug delivery, particularly for respiratory diseases via pulmonary drug delivery systems. These advanced formulations improve patient outcomes and healthcare efficiency.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Respiratory Medicine
Background:
- Enhanced therapeutics, derived from generics, offer improved patient benefits and represent low-risk innovation.
- Pulmonary drug delivery is crucial for treating chronic respiratory diseases and delivering complex drugs unsuitable for oral administration.
- Dry powder inhalation systems aim for targeted deep lung delivery through optimized formulation, packaging, and device design.
Purpose of the Study:
- To review advancements in pulmonary drug delivery for enhanced therapeutics.
- To highlight the importance of formulation, packaging, and device in dry powder inhalation systems.
- To discuss methodologies for testing and regulatory pathways for orally inhaled products.
Main Methods:
- Review of existing literature on pulmonary drug delivery and enhanced therapeutics.
- Analysis of dry powder inhalation system components: formulation, primary packaging, and device.
- Examination of non-clinical and clinical performance testing methodologies.
Main Results:
- Pulmonary drug delivery is a key route for treating respiratory ailments and systemic delivery of complex drugs.
- Optimization of dry powder inhalation systems involves a multi-faceted approach.
- Established regulatory pathways exist for orally inhaled products.
Conclusions:
- Pulmonary drug delivery is a significant area for future innovation in treating lung diseases.
- Enhanced therapeutics via inhalation offer a promising avenue for improved patient care.
- Continued research is vital for optimizing drug delivery to the deep lung.
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