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Updated: May 17, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Original β,γ-diamino acid as an inducer of a γ-turn mimic in short peptides
Sophie Thétiot-Laurent1, Francelin Bouillère, Jean-Pierre Baltaze
1Laboratoire de Chimie des Procédés et Substances Naturelles, ICMMO, UMR 8182, Univ Paris-Sud, CNRS, Bât 410, Orsay F-91405, France.
Abstract:
Original αγα tripeptides containing one β,γ-diamino acid have been synthesized and their conformation determined by extensive NMR and molecular dynamic studies. These studies revealed the presence of a C(9) hydrogen bonded turn around the β,γ-diamino acid which was stabilized by bulky side chains of the preceding residue. This turn can be considered as a mimic of the well-known γ-turn.
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