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Related Experiment Video

Updated: May 17, 2026

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
10:55

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

In vivo tracking techniques for cellular regeneration, replacement, and redirection.

Erik H J G Aarntzen1, Mangala Srinivas, Piotr Walczak

  • 1Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. E.Aarntzen@nucmed.umcn.nl

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|November 13, 2012
PubMed
Summary

Cellular therapy uses transplanted cells to heal tissues or restore function. In vivo cell tracking is crucial for optimizing these complex treatments and ensuring their clinical success.

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Biotechnology

Background:

  • Cellular therapy involves transplanting living cells to treat diseases.
  • Key goals include tissue regeneration, functional replacement via secreted molecules, and correcting aberrant biological processes.
  • The complexity of cellular therapies necessitates robust methods for monitoring transplanted cells within the body.

Purpose of the Study:

  • To review recent advancements in in vivo cell tracking technologies.
  • To highlight the importance of cell tracking for the clinical implementation of cellular therapy.
  • To provide an overview of how tracking aids in evaluating therapeutic benefits and optimizing treatment strategies.

Main Methods:

  • Review of current literature on in vivo cell tracking techniques.
  • Analysis of technologies enabling real-time monitoring of transplanted cells.
  • Synthesis of data on the application of cell tracking in preclinical and clinical settings.

Main Results:

  • Significant progress has been made in developing sophisticated in vivo cell tracking methods.
  • These tracking technologies are essential for assessing cell viability, migration, and biodistribution post-transplantation.
  • Effective cell tracking directly contributes to the validation and refinement of cellular therapy protocols.

Conclusions:

  • In vivo cell tracking is an indispensable tool for advancing cellular therapy.
  • Continued development and application of tracking technologies will accelerate the clinical translation of cell-based treatments.
  • Optimized tracking strategies are key to realizing the full therapeutic potential of cellular therapies.