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Related Concept Videos

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability10:56

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Apoptosis01:30

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Related Experiment Video

Updated: Jan 20, 2026

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability
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Retinal endothelial cell apoptosis.

Jena J Steinle1

  • 1Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 768A, Memphis, TN 38163, USA. jsteinl1@uthsc.edu

Apoptosis : an International Journal on Programmed Cell Death
|November 13, 2012
PubMed
Summary
This summary is machine-generated.

Retinal endothelial cell (REC) apoptosis is triggered by stressors common in eye diseases. Understanding REC apoptosis mechanisms and developing therapeutics are crucial for treating ocular conditions.

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Molecular Medicine

Background:

  • Retinal endothelial cell (REC) apoptosis is implicated in various ocular diseases.
  • Stressors like high glucose, oxidative stress, and hypoxia induce REC apoptosis.
  • Understanding REC apoptosis is critical for developing effective treatments for eye conditions.

Purpose of the Study:

  • To review current research on retinal endothelial cell (REC) apoptosis.
  • To discuss models used for studying REC apoptosis in ophthalmological research.
  • To explore mechanisms and potential therapeutics for preventing REC apoptosis.

Main Methods:

  • Literature review of ophthalmological research models for REC.
  • Analysis of cellular mechanisms driving REC apoptosis.
  • Examination of therapeutic strategies for preventing REC apoptosis.

Main Results:

  • Multiple stressors contribute to REC apoptosis.
  • Various research models exist for studying REC apoptosis.
  • Therapeutic interventions are under development to prevent REC apoptosis.

Conclusions:

  • REC apoptosis is a key process in ocular disease pathogenesis.
  • Further research into REC apoptosis mechanisms and therapeutics is warranted.
  • This review provides a foundation for future investigations in REC apoptosis.