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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...

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Related Experiment Video

Updated: May 17, 2026

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
08:54

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure

Published on: October 22, 2019

Autophagy and role in asthma.

Soma S S K Jyothula1, N Tony Eissa

  • 1Department of Medicine, The Methodist Hospital/Weill Cornell Medical College, Houston, Texas 77030, USA. ssjyothula@tmhs.org

Current Opinion in Pulmonary Medicine
|November 13, 2012
PubMed
Summary

Autophagy, a cellular process, plays a role in asthma pathogenesis and immune responses to respiratory viruses. Genetic variations in autophagy genes are linked to asthma, suggesting new therapeutic targets.

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Last Updated: May 17, 2026

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
08:54

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Published on: October 22, 2019

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

  • Immunology
  • Cellular Biology
  • Respiratory Medicine

Background:

  • Asthma is a prevalent respiratory illness marked by airway inflammation and increased susceptibility to viral infections.
  • Autophagy, a cellular degradation process, is crucial for immune function and antiviral responses.
  • Asthma involves complex immune pathways, including Th2 responses, and is influenced by genetic factors.

Purpose of the Study:

  • To review the role of autophagy in immune cell function and antiviral responses.
  • To explore the emerging evidence linking autophagy to asthma pathogenesis and its association with respiratory viral infections.

Main Methods:

  • Review of recent studies on autophagy's effect on viral replication and immune responses.
  • Examination of research investigating the association between autophagy and asthma.
  • Analysis of studies on genetic polymorphisms in autophagy genes and their impact on asthma.

Main Results:

  • Autophagy influences immune responses to common respiratory viruses.
  • Recent studies indicate a significant association between autophagy and asthma.
  • Genetic variations in autophagy-related genes are linked to asthma development and gene expression.

Conclusions:

  • Autophagy plays a complex role in asthma, offering insights into disease pathogenesis.
  • Modulating autophagy presents a potential new therapeutic strategy for treating asthma.