Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Venous Thrombosis IV: Nursing Management

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Randomized, Double-Blind, Placebo-Controlled Trial of Abatacept for the Treatment of Relapsing, Nonsevere Granulomatosis With Polyangiitis.

Arthritis & rheumatology (Hoboken, N.J.)·2025

Same author

The 2024 Vasculitis Foundation Quality Care Summit: Seeking Strategies to Improve Care for All Patients.

Arthritis & rheumatology (Hoboken, N.J.)·2025

Same author

Stroke frequency, associated factors, and clinical features in primary systemic vasculitis: a multicentric observational study.

Journal of neurology·2024

Same author

VEXAS-Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort.

Arthritis & rheumatology (Hoboken, N.J.)·2024

Same author

Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial.

Annals of the rheumatic diseases·2023

Same author

Vasculitis Mimics and Other Related Conditions.

Rheumatic diseases clinics of North America·2023

Search research articles

Related Experiment Video

Updated: May 17, 2026

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

Thrombosis in vasculitis.

Jason Springer¹, Alexandra Villa-Forte

¹Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, Ohio 44195, USA. springj2@ccf.org

Current Opinion in Rheumatology

|November 13, 2012

Summary

Systemic vasculitis increases the risk of venous and arterial thrombosis, leading to significant morbidity. Further research into thrombosis mechanisms in vasculitis is needed to improve patient outcomes and identify high-risk individuals.

Area of Science:

Rheumatology
Hematology
Immunology

Background:

Systemic inflammatory diseases, including vasculitis, are increasingly linked to heightened risks of both venous and arterial thrombosis.
Thromboembolic events represent a significant complication in several forms of systemic vasculitis, contributing to substantial morbidity and mortality.

Purpose of the Study:

To review the association between thrombosis and vasculitis.
To discuss proposed causal mechanisms linking these conditions.

Main Methods:

Literature review of studies investigating thrombosis in vasculitis.
Analysis of proposed pathophysiological mechanisms.

Main Results:

Evidence suggests an increased incidence of thromboembolic disease in antineutrophil cytoplasmic antibody-associated vasculitis, particularly during active disease phases.

More Related Videos

Venous Thrombosis Assay in a Mouse Model of Cancer

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Published on: December 22, 2017

Related Experiment Videos

Last Updated: May 17, 2026

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

Venous Thrombosis Assay in a Mouse Model of Cancer

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Published on: December 22, 2017

Increased risk of ischemic heart disease observed in vasculitis patients.

Immunosuppression shows promise in managing venous thrombosis in Behçet's disease.

Aspirin may play a role in preventing ischemic events in Takayasu's disease.

Conclusions:

Thromboembolic disease is a critical complication of systemic vasculitis, impacting patient morbidity and mortality.
Unanswered questions remain regarding screening, prevention, and anticoagulation duration for patients with vasculitis.
Future research focusing on the mechanisms of thrombosis and its inflammatory links is crucial for risk prediction and improved outcomes.