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Conducting Respiratory Oscillometry in an Outpatient Setting

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Proxy-reported questionnaires for young children with asthma: a structured review.

Amy Barrett¹, Marci Clark, Carla Demuro

¹RTI Health Solutions, Manchester, UK. abarrett@rti.org

The European Respiratory Journal

|November 13, 2012

Summary

This study identified and evaluated proxy-reported outcome measures for young children with asthma. The Pediatric Asthma Caregiver Diary showed the strongest measurement properties for clinical trials.

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Area of Science:

Pediatric Pulmonology
Clinical Trial Methodology
Health Outcomes Research

Background:

Accurate assessment of asthma in children under 6 is challenging.
Validated proxy-reported outcome measures are crucial for clinical trials.
Existing measures require evaluation for suitability as trial endpoints.

Purpose of the Study:

To identify proxy-reported outcome measures for asthma in children aged 6 years and younger.
To assess the measurement properties of these instruments.
To determine their suitability as endpoints in pediatric asthma clinical trials.

Main Methods:

A two-phase literature search was conducted using databases like PubMed and EMBASE.
Instruments were assessed against predefined criteria for relevance and measurement properties.
A total of 631 records were initially screened, identifying 20 instruments.

Main Results:

Seven pediatric asthma proxy-reported outcome instruments met the inclusion criteria.
These included the Childhood Asthma Control Test and the Pediatric Asthma Caregiver Diary.
Three instruments were deemed suitable for clinical trials, with the Pediatric Asthma Caregiver Diary showing the strongest properties.

Conclusions:

The Pediatric Asthma Caregiver Diary is a robust measure for assessing asthma in young children.
This instrument demonstrates strong measurement properties, supporting its use in clinical trials.
Further validation of pediatric asthma outcome measures is essential for advancing research.