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Proxy-reported questionnaires for young children with asthma: a structured review

Amy Barrett1, Marci Clark, Carla Demuro

  • 1RTI Health Solutions, Manchester, UK. abarrett@rti.org

The European Respiratory Journal
|November 13, 2012
PubMed

Insights

This study identified and evaluated proxy-reported outcome measures for young children with asthma. The Pediatric Asthma Caregiver Diary showed the strongest measurement properties for clinical trials.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Trial Methodology
  • Health Outcomes Research

Background:

  • Accurate assessment of asthma in children under 6 is challenging.
  • Validated proxy-reported outcome measures are crucial for clinical trials.
  • Existing measures require evaluation for suitability as trial endpoints.

Purpose of the Study:

  • To identify proxy-reported outcome measures for asthma in children aged 6 years and younger.
  • To assess the measurement properties of these instruments.
  • To determine their suitability as endpoints in pediatric asthma clinical trials.

Main Methods:

  • A two-phase literature search was conducted using databases like PubMed and EMBASE.
  • Instruments were assessed against predefined criteria for relevance and measurement properties.
  • A total of 631 records were initially screened, identifying 20 instruments.

Main Results:

  • Seven pediatric asthma proxy-reported outcome instruments met the inclusion criteria.
  • These included the Childhood Asthma Control Test and the Pediatric Asthma Caregiver Diary.
  • Three instruments were deemed suitable for clinical trials, with the Pediatric Asthma Caregiver Diary showing the strongest properties.

Conclusions:

  • The Pediatric Asthma Caregiver Diary is a robust measure for assessing asthma in young children.
  • This instrument demonstrates strong measurement properties, supporting its use in clinical trials.
  • Further validation of pediatric asthma outcome measures is essential for advancing research.

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