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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Mean platelet volume in neonatal sepsis
Mehmet Yekta Oncel1, Ramazan Ozdemir, Sadik Yurttutan
1Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. dryekta@gmail.com
Journal of Clinical Laboratory Analysis
|November 13, 2012
Summary
Neonatal sepsis (NS) is associated with higher mean platelet volume (MPV) levels. This study found significantly elevated MPV in newborns with sepsis compared to healthy controls, indicating MPV as a potential sepsis biomarker.
Area of Science:
- Neonatology
- Hematology
- Pediatric Infectious Diseases
Background:
- Neonatal sepsis (NS) is a serious condition in newborns.
- Investigating reliable biomarkers for NS is crucial for early diagnosis and treatment.
Purpose of the Study:
- To determine if mean platelet volume (MPV) differs in newborns with NS compared to healthy controls.
- To explore MPV as a potential diagnostic marker for neonatal sepsis.
Main Methods:
- Stratified 100 newborns with NS into proven (Group 1a) and clinical (Group 1b) sepsis.
- Included 50 healthy newborns as controls (Group 2), matched for gestational age and birth weight.
- Analyzed baseline levels of white blood cell count (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), and MPV.
Main Results:
- Newborns with NS exhibited significantly higher WBC, CRP, IL-6, and MPV levels than healthy controls (P < 0.01 for all).
- Group 1a (proven sepsis) showed higher baseline CRP and MPV than Group 1b (clinical sepsis) (P < 0.007).
- No significant difference in IL-6 or platelet count between sepsis groups.
Conclusions:
- This study is the first to report a statistically significant difference in baseline MPV values between newborns with sepsis (proven or clinical) and healthy controls.
- Elevated MPV may serve as a valuable indicator in the diagnosis of neonatal sepsis.
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