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Ewing sarcoma of the hand or foot
1Westfalian Wilhelms University Muenster, Muenster, Germany.
Klinische Padiatrie
|November 13, 2012
Summary
Ewing sarcoma of the hand or foot has a favorable outcome, with no significant difference between surgical or radiotherapy local treatments. Primary disease dissemination is the main factor impacting survival.
Area of Science:
- Oncology
- Orthopedic Oncology
- Pediatric Oncology
Background:
- Ewing sarcoma (ES) of the hand or foot is a rare malignancy.
- Optimal local control is crucial for function and outcomes in these critical sites.
Purpose of the Study:
- To evaluate the effectiveness of different local therapeutic options for Ewing sarcoma of the hand or foot.
- To compare outcomes of surgery (OP), surgery with radiotherapy (OP & RT), and radiotherapy (RT) alone for local control.
Main Methods:
- Analysis of data from 80 patients with ES of the hand or foot treated between 1991 and 2009.
- All patients received chemotherapy; local therapy included OP (39%), OP & RT (44%), RT (12%), or no local therapy (5%).
- Primary endpoint was event-free survival (EFS).
Main Results:
- Overall 3-year EFS was 62%. Localized disease had a significantly better EFS (77%) than disseminated disease (30%).
- No significant difference in EFS was observed between OP (61%), OP & RT (66%), and RT alone (70%).
- Patients receiving no local treatment had an unfavorable prognosis (3-year EFS=25%). Primary dissemination was the only significant prognostic factor.
Conclusions:
- Ewing sarcoma of the hand or foot is associated with a favorable outcome.
- Primary disease dissemination is the most significant prognostic factor.
- The study, with a limited patient group, did not identify a preferred local treatment modality.
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