Related Experiment Video
Updated: May 17, 2026

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
Published on: November 6, 2017
NMDA receptor signaling: death or survival?
Tong Luo1, Wei-Hua Wu, Bo-Shiun Chen
1Institute of Molecular Medicine and Genetics, Department of Neurology, Georgia Health Sciences University, Augusta, GA 30912, USA.
None:
Glutamate-induced neuronal damage is mainly caused by overactivation of N-methyl-D-aspartate (NMDA) receptors. Conversely, normal physiological brain function and neuronal survival require adequate activation of NMDA receptors. Studies have revealed that NMDA receptor-induced neuronal death or survival is mediated through distinct subset of NMDA receptors triggering different intracellular signaling pathways. Here we discuss recent advances in the characterization of NMDA receptors in neuronal protection, emphasizing subunit-specific role, which contributes to temporal-spatial distribution, subcellular localization and diverse channel properties of NMDA receptors.
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