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Association of arterial stiffness and electrocardiography-determined left ventricular hypertrophy with left

Po-Chao Hsu1, Wei-Chung Tsai, Tsung-Hsien Lin

  • 1Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Plos One
|November 13, 2012
PubMed

Insights

Higher arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), and electrocardiography-determined left ventricular hypertrophy (LVH) are independently linked to left ventricular diastolic dysfunction (LVDD). These factors help identify individuals at high risk for LVDD.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Diagnostic Imaging

Background:

  • Increased arterial stiffness is linked to left ventricular diastolic dysfunction (LVDD).
  • Left ventricular hypertrophy (LVH) influences left ventricular (LV) performance and is correlated with LVDD.
  • The interplay between arterial stiffness, LVH, and LVDD requires further investigation.

Purpose of the Study:

  • To compare LV diastolic function in patients stratified by brachial-ankle pulse wave velocity (baPWV) and electrocardiography (ECG)-determined LVH.
  • To determine if elevated baPWV and ECG-determined LVH are independent predictors of LVDD.

Main Methods:

  • A cross-sectional study of 270 patients categorized into four groups based on median baPWV and presence/absence of ECG-determined LVH.
  • baPWV measured using an ABI-form device; LVH defined by Sokolow-Lyon criterion.
  • LVDD defined by impaired relaxation, pseudonormal, or restrictive mitral inflow patterns.

Main Results:

  • Early diastolic mitral velocity (Ea) decreased progressively across the four groups.
  • The group with high baPWV and LVH exhibited the highest prevalence of LVDD.
  • Both baPWV and ECG-determined LVH were independent predictors of reduced Ea and increased LVDD risk.

Conclusions:

  • Patients with higher baPWV and ECG-determined LVH have poorer LV diastolic function and higher LVDD prevalence.
  • baPWV and ECG-determined LVH are independently associated with Ea and LVDD.
  • Assessing arterial stiffness (baPWV) and LVH (ECG) can identify individuals at high risk for LVDD.
Abstract

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