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Updated: May 16, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

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Published on: February 20, 2021

TRPV1 and SP: key elements for sepsis outcome?

Jennifer Victoria Bodkin1, Elizabeth Soares Fernandes

  • 1Centre for Microvascular Research, Queen Mary, University of London, London, UK.

British Journal of Pharmacology
|November 14, 2012
PubMed
Summary

Sensory neurons, particularly the TRPV1 receptor and substance P, significantly influence sepsis outcomes. Targeting these pathways may offer new therapeutic strategies for this life-threatening inflammatory condition.

Keywords:
TRPV1sensory neuronessepsissubstance P

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Last Updated: May 16, 2026

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Published on: June 15, 2019

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Sepsis is a life-threatening systemic inflammatory response to infection.
  • Current sepsis treatments are limited, necessitating novel therapeutic approaches.
  • Sensory neurons and their mediators are increasingly recognized for their role in inflammatory diseases.

Purpose of the Study:

  • To review the role of sensory neurons in modulating sepsis.
  • To highlight the involvement of the TRPV1 receptor and substance P in sepsis.
  • To emphasize the protective potential of TRPV1 in sepsis.

Main Methods:

  • Literature review focusing on sensory neurons, TRPV1, and substance P in sepsis.
  • Analysis of existing research on the mechanisms of sepsis pathology.
  • Synthesis of findings on the transition from local to systemic inflammation.

Main Results:

  • Sensory neurons, TRPV1, and substance P are key players in sepsis.
  • These mediators influence the transition from local infection to systemic inflammation.
  • TRPV1 exhibits a protective role in the context of sepsis.

Conclusions:

  • Sensory neurons are crucial modulators of sepsis.
  • TRPV1 and substance P represent important therapeutic targets for sepsis.
  • Further research into TRPV1's protective mechanisms could lead to improved sepsis treatments.